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Itis not uncommon for this treatment approach to causepatients to become frustrated and exhibit an exacerba-tion of their behaviors. However, the shape of the dose–response curve in the low-dose region can vary substantiallyamong models (see Figure 23.5)

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Patients in the zinc-treated group experienced less severesymptoms by day four of the study compared with patients in the placebo-treated group.

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